P: For use and supply by all optometrists.
Otrivine-Antistin: eye drops, 0.5% antazoline sulphate, 0.05% xylometazoline hydrochloride (Spectrum Thea)
For the temporary relief of redness and itching of the eye due to seasonal and perennial allergies such as hay fever or house dust allergy.
See Clinical Management Guideline on Conjunctivitis- seasonal and perennial allergic
Hypersensitivity to antazoline, xylometazoline or any component of the preparation. Should not be used in patients taking monoamine oxidase inhibitors within the last 14 days.
The only preparation available in the UK contains xylometazoline, which is a sympathomimetic and should be avoided in patients at risk of angle closure glaucoma. Use with caution in elderly patients with severe cardiovascular disease, including arrhythmia, poorly controlled hypertension, or diabetes. Similarly, sympathomimetics should also be used with caution in the presence of hypertension, cardiac irregularities, hyperthyroidism diabetes mellitus or phaeochromocytomas, also in patients with conditions causing urinary retention such as prostatic hypertrophy or patients who are currently receiving other sympathomimetic drugs.
Contact lens wear should not be worn during treatment. Preparation contains benzalkonium chloride as a preservative, which may accumulate in soft lenses and cause irritation.
Pregnancy and Lactation
Pregnancy risk category C. Safety in pregnancy has not been established. Should be used with caution during pregnancy and only if the expected benefit to the mother is greater than any possible risk to the developing foetus.
It is not known whether antazoline is excreted in breast milk. Its use in nursing mothers therefore requires that the benefits be weighed against the potential risks to the infant.
Should not be used in patients receiving monoamine oxidase inhibitors or within 14 days of stopping such treatment (risk of hypertensive crisis). Should be used with caution in patients receiving other medications such as digitalis, beta-adrenergic blockers, guanetidine, reserpine, methyldopa or anti-hypertensive agents.
Sedating anti-histamines can enhance the sedating effects of CNS depressants including alcohol, hypnotics, opioid analgesics, anxiolytic sedatives, and anti-psychotics. They also have an additive anti-muscarinic action with other anti-muscarinic drugs, such as atropine, and some antidepressants
In the case of concomitant use of another topical eye preparation, allow 5-10 minutes between applications of each preparation.
Adults & children (12 years and over) apply 1 drop two to three times daily.
Ocular Side Effects
Local allergic reaction (rash, oedema, pruritus)
Acute closed angle glaucoma
Ocular Side Effects-Notes
Rebound hyperaemia may occur. Ocular side effects are uncommon and typically transient. Xylometazoline is a sympathomimetic and may precipitate angle closure glaucoma in susceptible individuals. Recent case reports of severe follicular conjunctivitis.
General Side Effects
General Side Effects-Notes
Store below 25șC.